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[DOI] [PubMed] [Google Scholar] 192.de Kloet E.R., de Kloet S.F., de Kloet C.S., de Kloet A.D

Cisplatin has been known to bind to guanine with much greater preference over adenine, which is somewhat surprising because it could be argued that the inductive effects of the electron-withdrawing oxo group at the C6 position of guanine should reduce the electron density at N7 compared to adenine that has an electron-donating amino group at the C6 position, thus making the N7 of guanine less nucleophilic compared to adenine (Mantri and Baik, 2006)

Hormonal control is by the action of glucagon, epinephrine (adrenaline) and cortisol

3.2 Cognitive decline and Alzheimers disease Recent human and animal research has emphasized the importance of choline intake in preventing neurodegenerative diseases such as Alzheimers disease (163)